《人类清除计划5》讲述在选举年结束以后，阿德拉和胡安从墨西哥毒贩的手中逃出来，成功偷渡到美国以后，却赶上了当地人类清洗计划的故事。选举年结束，阿德拉和胡安夫妻从墨西哥成功进入美国，并在接下来的10个月时间里，两个人都在美国德克萨斯州的一个牧场工作，当地牧场的族长对待胡安夫妻很好，但是族长的儿子却对这对夫妻虎视眈眈

正赶上胡安的妻子生产，在妻子生下孩子，完成清洗以后，牧场上的暴力和杀戮仍然在继续，这对夫妻并没有意识到，一个阴暗的团体组织已经开始浮出水面，他们致力于完成“永远的清洗”，这片土地上的任何一条人命都不放过，并决心让这个国家从此摆脱移民，他们还将目标瞄准了富人，这使得胡安夫妇被迫全副武装，与这个组织进行对抗。

"Purge 5" tells the story of Adela and Juan escaping from Mexican drug dealers after the election year and successfully smuggling to the United States Later, they caught up with the story of the local human cleansing plan. At the end of the election year, Adela and Juan successfully entered the United States from Mexico. In the next 10 months, both of them worked on a ranch in Texas. The patriarch of the local ranch treated Juan The husband and wife are very good, but the patriarch's son is eyeing the couple

Just in time for Juan's wife to give birth, after the wife gave birth and finished cleaning, the violence and killing on the ranch is still going on Continuing, unbeknownst to the couple, a shadowy group has begun to surface dedicated to completing the "Forever Cleansing" that will take every life from the land and are determined to bring the country back to life. Getting rid of immigrants, they also targeted the rich, which forced the Juan couple to be fully armed and confronted with this organization.